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As a prophecy of doom unfolds on the peaceful land of Britannia, a purehearted boy sets out on a journey of discovery — and revenge.

The story begins when high school student Kazuki Muto is killed one night saving a mysterious girl from a monster, only to wake up in his school dorm, believing it to have been a dream; however, he soon finds out that dream wasn't a dream at all when a giant serpentine monster attacks him and his sister. Tokiko Tsumura, the girl he saved, explains that the monster is a homunculus. Kazuki had been attacked and killed by it when he was rescuing her; however, she, feeling responsible for him, revived him by placing a Kakugane medallion in his chest, serving as a replacement heart.

When Hikari was little, she and her father liked to watch professional wrestling, and she became very good at it. She is the pride of her family until she is introduced to Kei, the son of her father's friend.

Yuru, a young hunter, lives in a small village deep in the mountains, hunting wild game and leading a humble life with Asa, his younger twin sister. Their peaceful lives are torn apart when a dragon’s roar echoes across the sky. What secrets lurk within their village? What fate awaits them?

Ko Ichinomiya's family motto is "Never be indebted to anyone," but after losing his pants and falling into the Arakawa River, he quickly finds himself in debt to his savior, the cutely insane Nino who happens to live under the bridge. To repay her, he vows to help her with her desire to "experience love." Along the way he'll meet the river's other residents, including a hot-blooded kappa, a Sister in drag, and a literal rock star.

The swordsmith Amon accidentally comes across an infant and its dead mother in the forest. Although he is initially overwhelmed by the situation, he finally decides to take the boy with him and thus save him from certain death. Ten years after this fateful encounter, the boy from that time, Gai, is apprenticed to Amon. While making a sword, however, there is a tragic accident in which Gai loses his right arm. Amon then decides to use a sword called Shiryuu to make an artificial arm for Gai. Thus, it begins…

Itsuki Minami is a school student notorious for engaging in street fights, a reckless punk that will break through any obstacle, alongside his best friends Kazuma Mikura and Onigiri. However, when he discovers a pair of Air Trecks his true desire to rule the skies takes off.

On the run from a past crime, Juzo Fujimaki is blackmailed into joining an illicit tournament and has to face top martial artists in deadly match-ups.

Kouta has girl troubles of the supernatural sort. For some reason, he keeps attracting the attention (and affections) of animal spirits! Having spent most of his life in the country, Kouta is understandably nervous when he moves in with his grandma to attend a high school in the big city. He hoped to make a good impression, but having Chizuru, a beautiful fox spirit, hanging off his arm didn't seem to be the sort of image he wanted to have. She's not alone in her love for Kouta, either. Nozomu, a wolf spirit, as well as other youkai have their sights set on the hapless country boy.

To gain the skills he needs to surpass his powerful father, Baki enters Arizona State Prison to take on the notorious inmate known as Mr. Unchained.

The democratic nation of Patria was created on the continent of Patria. Because of economical disputes, the country split north and south, creating the Northern Union of Patria and the Southern Confederation of Patria and they waged a long civil war. With their numbers dwindling, the North decides to use forbidden technology in order to defeat the South. This technology turns humans into monster-like soldiers, giving them almost godlike powers. And with those powers, the long war came to an end and peace was restored.

Miaka, a junior high school student in Tokyo, has normal problems: fights with her mom, entrance exams, and deciding where she's going to go eat with her friends. But when she finds a mysterious book in the library, her life is changed forever when she and her best friend are transported inside!