Muhammed DeReese

The PFL 6 mixed martial arts event for the 2021 season of the Professional Fighters League was held on June 25, 2021. This was the third regular season event of the tournament and included fights in the Heavyweight and women's Lightweight divisions. This event will aire on ESPN2, with the prelims on ESPN+. The event was headlined by Two-time Olympic gold medalist Kayla Harrison and Cindy Dandois.

The PFL 8 mixed martial arts event for the 2021 season of the Professional Fighters League was held on August 19, 2021. This was the second event for of the playoffs with the Heavyweight and Women's Lightweight divisions competing. This event aired on ESPN, with the prelims on ESPN+. Kayla Harrison, the only two-time Olympic gold medalist in judo in the history of the United States, entered her second PFL playoffs unbeaten in 10 pro bouts. She faced Genah Fabian who held a 4-1 record and had won both of her PFL regular season bouts against Julija Pajic and Laura Sanchez to advance to the playoffs.

The event was headlined by a heavyweight bout, contested by the former UFC Heavyweight champion Fabrício Werdum and Renan Ferreira. In the co-main event, the 2019 PFL Lightweight champion Kayla Harrison fought Mariana Morais.