This Might Hurt

An extremely wealthy elderly man dying from cancer undergoes a radical medical procedure that transfers his consciousness to the body of a healthy young man but everything may not be as good as it seems when he starts to uncover the mystery of the body's origins and the secret organization that will kill to keep its secrets.

A cynical radio host is banished to Colorado, where he has an on-air spat with a hopeless romantic. Soon, their antagonistic relationship sparks the interest of the whole town.

Lorenzo Odone, a Virginia 5-year-old, develops a degenerative nerve disease so rare that nobody is working on a cure, so his parents decide to immerse themselves in research and tackle the problem themselves.

After his happy life spins out of control, a preacher from Texas changes his name, goes to Louisiana and starts preaching on the radio.

A Midwestern husband and father announces his plan to have a sex change operation.

A world-weary college professor is given a life-changing diagnosis and decides to throw all pretense and conventions to the wind and live his life as boldly and freely as possible with a biting sense of humor, a reckless streak and a touch of madness.

A pair of high-frequency traders go up against their old boss in an effort to make millions in a fiber-optic cable deal.

A molecular biologist's study of the human eye has far-reaching implications about humanity's scientific and spiritual beliefs.

Something is rotten at the Elsinore Brewery. Bob and Doug McKenzie (as seen on SCTV) help the orphan Pam regain the brewery founded by her recently-deceased father. But to do so, they must confront the suspicious Brewmeister Smith and two teams of vicious hockey players.

A small-town doctor learns that the population of his community is being replaced by emotionless alien duplicates.

An ugly girl undergoes plastic surgery and becomes beautiful. She then takes revenge on all the people who mistreated her when she was ugly.

In what might be his most personal and introspective hour yet, Bill offers hilarious takes on everything from male sadness to dating advice.