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The film contains five stories set on desolate stretches of a desert highway. Two men on the run from their past, a band on its way to a gig, a man struggling to get home, a brother in search of his long-lost sister and a family on vacation are forced to confront their worst fears and darkest secrets in these interwoven tales.

A tale of love and violence when a man on his emotional last legs finds a savior seductively dancing in a run-down strip club. And a life most certainly headed off a cliff suddenly becomes redirected - as everything is now worth dying for.

A journey into uncharted and forbidden territory through three tales tangled in space and time.

Two women—Diana, a flamboyant and ruthless thief, and Evie, a seemingly innocent young woman with a troubled past—become embroiled in a series of horrific murders on the island of Malta.

Charles Dexter Ward, a wealthy scientist, uses an ancient diary and human remains to begin a terrifying and bloody pursuit for immortality.

Cocky researcher Sebastian Caine is working on a project to make living creatures invisible. Determined to achieve the ultimate breakthrough, Caine pushes his team to move to the next phase — using himself as the subject. The test is a success, but when the process can't be reversed and Caine seems doomed to future without flesh, he starts to turn increasingly dangerous.

On the surface it's believed to be another urban legend - a supernatural being from the afterlife is violently killing anyone who cheats on their significant other in the small college town of Silvercreek, Pennsylvania. But the town's unusually high suicide rate is finally convincing both locals and college students that everything is not as it seems. When Maeve - a female college student - sleeps with Charlie, the married man of the host family she is staying with, both sense the deadly curse is closing in on them. Unable to get anyone to believe them, Maeve and Charlie seek out a local history student to help find answers and figure out a way to defend themselves. It all comes undone, however, as several people are horrifically killed by the savage being - one-by-one at a rapid pace. Eventually, Maeve, Charlie and the few survivors band together in an attempt to defeat the monster once and for all.

When researchers rescue a fellow scientist who survived a meteorite strike in the Arctic, they discover she may not be who they think she is. Is she some-how changed?

Years after a mysterious plague has devastated the planet and turned most of humanity into blood-hungry creatures, a rogue drifter on a vengeful hunt stumbles across a band of survivors in an abandoned police station and reluctantly agrees to try to help them defend themselves and escape to the sanctuary they so desperately need.

When twin brothers arrive home to find their mother’s demeanor altered and face covered in surgical bandages, they begin to suspect the woman beneath the gauze might not be their mother.

Grindhouse combines Robert Rodriguez's Planet Terror, a horror comedy about a group of survivors who battle zombie-like creatures, and Quentin Tarantino's Death Proof, an action thriller about a murderous stuntman who kills young women with modified vehicles. It is presented as a double feature with fictitious exploitation trailers preceding each segment.

After fleeing his psychotic father, a young teen and his mom seek refuge in a remote farmhouse, only to face a pack of ferocious dogs and the sinister spirits that haunt the property.