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Grindhouse combines Robert Rodriguez's Planet Terror, a horror comedy about a group of survivors who battle zombie-like creatures, and Quentin Tarantino's Death Proof, an action thriller about a murderous stuntman who kills young women with modified vehicles. It is presented as a double feature with fictitious exploitation trailers preceding each segment.

Nearly a year after a botched job, a hitman takes a new assignment with the promise of a big payoff for three killings. What starts off as an easy task soon unravels, sending the killer into the heart of darkness.

A fur trapper leaves his wife and daughter behind to kill a rogue wolf in the remote wilderness, but they soon become increasingly worried when their peaceful existence is disrupted.

On the surface it's believed to be another urban legend - a supernatural being from the afterlife is violently killing anyone who cheats on their significant other in the small college town of Silvercreek, Pennsylvania. But the town's unusually high suicide rate is finally convincing both locals and college students that everything is not as it seems. When Maeve - a female college student - sleeps with Charlie, the married man of the host family she is staying with, both sense the deadly curse is closing in on them. Unable to get anyone to believe them, Maeve and Charlie seek out a local history student to help find answers and figure out a way to defend themselves. It all comes undone, however, as several people are horrifically killed by the savage being - one-by-one at a rapid pace. Eventually, Maeve, Charlie and the few survivors band together in an attempt to defeat the monster once and for all.

Retired military commander Colonel Dale Murphy hosts the simulated post-apocalyptic reality show where participants are challenged to survive a remote West Virginia wasteland. But the show turns into a nightmarish showdown when each realizes they are being hunted by an inbred family of cannibals determined to make them all dinner!

A boy named Harley and his family attend a taping of The Banana Splits TV show, which is supposed to be a fun-filled birthday for young Harley and business as usual for Rebecca, the producer of the series. But things take an unexpected turn - and the body count quickly rises. Can Harley, his mom and their new pals safely escape?

Two doctors find their graveyard shift inundated with townspeople ravaged by sores. Among the wounded is Cherry Darling, a dancer whose leg was ripped from her body. As the invalids quickly become enraged aggressors, Cherry and her ex-boyfriend El Wray lead a team of accidental warriors into the night.

A teenager's weekend at a lake house with her father takes a turn for the worse when a group of convicts wreaks havoc on their lives.

A couple’s romantic vacation at a secluded lakeside estate is upended when they are forced to share the mansion with a mysterious and attractive couple. In this darkly hilarious and seductive horror story, a dream getaway spirals into a nightmarish maze of sex, lies, and manipulation, bringing terrifying secrets to light and triggering a bloody battle for survival.

A woman on the run from her abusive husband encounters a mysterious hitch-hiker.

The film contains five stories set on desolate stretches of a desert highway. Two men on the run from their past, a band on its way to a gig, a man struggling to get home, a brother in search of his long-lost sister and a family on vacation are forced to confront their worst fears and darkest secrets in these interwoven tales.

A wisecracking reporter investigates the cannibalistic 'Moon Killer' murders tied to a medical academy, culminating in a chilling reenactment experiment.