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The film contains five stories set on desolate stretches of a desert highway. Two men on the run from their past, a band on its way to a gig, a man struggling to get home, a brother in search of his long-lost sister and a family on vacation are forced to confront their worst fears and darkest secrets in these interwoven tales.

Anna suffers from agoraphobia so crippling that when a trio of criminals break into her house, she cannot bring herself to flee. But what the intruders don't realize is that agoraphobia is not her only psychosis.

Romulus, a misunderstood musician turned recluse hiding from personal demons in a New York City cave, finds the frozen body of a young drifter in a tree. The authorities, including his police officer daughter, claim the death is accidental. Romulus is convinced the man was murdered by a prominent art photographer but how can he prove he's right when everyone thinks he's insane?

A troubled young woman becomes obsessed with her mysterious new neighbor, who bears a striking resemblance to the girl's dead mother.

20 men are chosen to participate in the roles of guards and prisoners in a psychological study that ultimately spirals out of control.

When a gloomy, God-fearing island community is rocked by the assault of an infant, a psychiatrist is called in to examine Dorothy Mills, the teenager accused of the crime. Despite the villagers' hostility to her inquiry, she soon comes to suspect that Dorothy suffers from multiple personality disorder...

Clinging to a smooth, curved surface high above a sentient abyss, a woman tries to cover the few feet back to safety without losing purchase and falling to her death.

A group of officers based in a labyrinthine top-secret prison must fight for their lives against Hatchet, a brilliant and infamous high-value detainee. When he escapes, his mysterious and deadly agenda has far reaching and dire consequences.

A reporter, fired after refusing to give names to a 1951 House Un-American Activities Committee, takes a part-time job as companion to an old lady. While working she overhears a noisy argument in the neighboring house, being conducted largely in German and involving her HUAC prosecutor. She begins to investigate, enlisting the help of the FBI Agent initially detailed to surveil her.

A fashion designer suffers from a mysterious illness that puzzles her doctors and frustrates her husband until help arrives in the form of a Filipino caregiver who uses traditional folk healing to reveal a horrifying truth.

When a law student accidentally kills the son of a mob boss in a fight, he finds himself relentlessly pursued by the mob and the police.

Set in a 19th century village, a young man studying under a local doctor joins a team of hunters on the trail of a wolf-like creature.