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Trevor, an insomniac lathe operator, experiences unusual occurrences at work and home. A strange man follows him everywhere, but no one else seems to notice him.

An Oxford Medical School graduate takes a position at a mental institution and soon becomes obsessed with a female mental patient, but he has no idea of a recent and horrifying staffing change.

An obese lawyer finds himself growing "Thinner" when an old Romani man places a hex on him. Now the lawyer must call upon his friends in organized crime to help him persuade the old man to lift the curse. Time is running out for the desperate lawyer as he draws closer to his own death, and grows ever thinner.

Five men wake up in a locked-down warehouse with no memory of who they are. They are forced to figure out who is good and who is bad to stay alive.

As he helps a young artist with her upcoming exhibition, the owner of a mannequin shop's deadly, suppressed desires come to the surface.

A severely injured man and woman awake in an abandoned sanitarium only to discover that a sadistic caretaker holds the keys to their freedom and the horrific answers as to their true identity.

Now confined to a mental hospital, young Kirsty insists her supposedly dead father is actually stuck in Hell following his wife’s betrayal. Few believe the young woman’s lurid stories aside from the thrill-seeking Dr. Channard. Kirsty is undeterred and, with the help of a fellow patient, heads to Hell for a rescue.

World War II soldier-turned-U.S. Marshal Teddy Daniels investigates the disappearance of a patient from a hospital for the criminally insane, but his efforts are compromised by troubling visions and a mysterious doctor.

Criminology student Chloe fakes her own death to break into a morgue, in order to retrieve a piece of evidence that ties her younger brother to a crime gone wrong. Once inside, she discovers that a sadistic coroner is using the corpses for his sick and twisted business, and when he realises that Chloe still has a pulse, a terrifying game of cat and mouse ensues.

Unable to conceive, a couple seeks to build a family with a young orphan, survivor of tragic childhood. But their act of love turns to horror when they realize the violence in their foster's past has returned to destroy the new family.

Jigsaw has disappeared. Along with his new apprentice Amanda, the puppet-master behind the cruel, intricate games that have terrified a community and baffled police has once again eluded capture and vanished. While city detectives scramble to locate him, Doctor Lynn Denlon and Jeff Reinhart are unaware that they are about to become the latest pawns on his vicious chessboard.

Grindhouse combines Robert Rodriguez's Planet Terror, a horror comedy about a group of survivors who battle zombie-like creatures, and Quentin Tarantino's Death Proof, an action thriller about a murderous stuntman who kills young women with modified vehicles. It is presented as a double feature with fictitious exploitation trailers preceding each segment.