Once in a Lifetime

A mentally ill young woman finds love with an eccentric man who models himself after Buster Keaton.

A teenage con artist tricks a desperate mother into hiring her as a live-in companion for her autistic daughter.

A wheelchair-bound singer and her best friend embark on a roadtrip to Memphis.

Simon has Asperger's syndrome and doesn't like changes in his life. He lives with his big brother Sam and Sam's girlfriend Frida. When Frida can't stand having to adapt to Simon's peculiarities anymore she takes off, leaving Simon with having to find a new, perfect, girlfriend for his brother.

A shy teenager living on the Isle of Wight dreams of pop stardom. With the help of an unlikely mentor, she enters a singing competition that will test her integrity, talent, and ambition.

Awkward, isolated and disapproving of most of the people around her, a precocious 19-year-old genius is challenged to put her convictions to the test by venturing out on to the NYC dating scene.

Alejandro is an aspiring toy designer from El Salvador, struggling to bring his unusual ideas to life in New York City. As time on his work visa runs out, a job assisting an erratic art-world outcast becomes his only hope to stay in the country and realize his dream.

Veteran drag queens Vida Boheme and Noxeema Jackson take novice Chi-Chi Rodriguez under their wing on a madcap road trip across the country to compete in the Drag Queen of America pageant in Los Angeles.

Phillip is a wealthy quadriplegic who needs a caretaker to help him with his day-to-day routine in his New York penthouse. He decides to hire Dell, a struggling parolee who's trying to reconnect with his ex and his young son. Despite coming from two different worlds, an unlikely friendship starts to blossom.

Devoted teacher Anne Sullivan leads deaf, blind and mute Helen Keller out of solitude and helps integrate her into the world.

Paul, a 20 year old midwesterner, arrives at the central bus station and quickly catches eyes with Wye, a 22 year old girl voguing on the sidewalk. After Paul seeks her out in secret, an intense love between them blossoms. But when Paul discovers Wye is trans, he is forced to confront his own identity and what it means to belong.

A younger sister wishes to switch places with her popular older sister and the two bickering siblings awaken to find the wish has come true.