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Leonard Shelby is tracking down the man who raped and murdered his wife. The difficulty of locating his wife's killer, however, is compounded by the fact that he suffers from a rare, untreatable form of short-term memory loss. Although he can recall details of life before his accident, Leonard cannot remember what happened fifteen minutes ago, where he's going, or why.

Mario, a worker in "lost and found" department, finds a suitcase with a dead baby inside.

Five men wake up in a locked-down warehouse with no memory of who they are. They are forced to figure out who is good and who is bad to stay alive.

Claiming that he doesn't know his own past, a rich man enlists an ex-con with an odd bit of detective work. Gregory Arkadin says he can't remember anything before the late 1920s, and convict Guy Van Stratten is happy to take the job of exploring his new acquaintance's life story. Guy's research turns up stunning details about his employer's past, and as his work seems linked to untimely deaths, the mystery surrounding Mr. Arkadin deepens.

A woman wakes up every day, remembering nothing as a result of a traumatic accident in her past. One day, new terrifying truths emerge that force her to question everyone around her.

Roy Freeman, an ex-homicide detective with a fractured memory, is forced to revisit a case he can't remember. As a man's life hangs in the balance on death row, Freeman must piece together the brutal evidence from a decade-old murder investigation, uncovering a sinister web of buried secrets and betrayals linking to his past. With only instincts to trust, he faces a chilling truth - sometimes, it's best to let sleeping dogs lie.

Psychiatrist Sam Foster has a new patient, Henry Letham, who claims to be suicidal. In trying to diagnose him, Sam visits Henry's prior therapist and also finds Henry's mother -- even though Henry has said that he murdered both of his parents. As reality starts to contradict fact, Sam spirals into an unstable mental state. Then he finds a clue as to how and when Henry may try to kill himself, and races to try to stop him.

A man awakens from a coma, only to discover that someone has taken on his identity and that no one, (not even his wife), believes him. With the help of a young woman, he sets out to prove who he is.

Frederick Fitzell is living his best life—until he starts having horrific visions of Cindy, a girl who vanished in high school. After reaching out to old friends with whom he used to take a mystery drug called Mercury, Fredrick realizes the only way to stop the visions lies deep within his own memories, so he embarks on a terrifying mental odyssey to learn the truth.

When Simon awakens in the hospital after surviving a near-fatal accident, amnesia has erased the last two years from his memory. He learns that his brother was killed, he has married a woman he doesn't remember and he's haunted by strange visions of the woman he loved.

Chris and his girlfriend Rose go upstate to visit her parents for the weekend. At first, Chris reads the family's overly accommodating behavior as nervous attempts to deal with their daughter's interracial relationship, but as the weekend progresses, a series of increasingly disturbing discoveries lead him to a truth that he never could have imagined.

A tight-knit team of FBI investigators, along with their District Attorney supervisor, is suddenly torn apart when they discover that one of their own teenage daughters has been brutally murdered.