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Blank-faced bug killer Bill Lee and his dead-eyed wife, Joan, like to get high on Bill's pest poisons while lounging with Beat poet pals. After meeting the devilish Dr. Benway, Bill gets a drug made from a centipede. Upon indulging, he accidentally kills Joan, takes orders from his typewriter-turned-cockroach, ends up in a constantly mutating Mediterranean city and learns that his hip friends have published his work -- which he doesn't remember writing.

Writer Harry Block draws inspiration from people he knows, and from events that happened to him, sometimes causing these people to become alienated from him as a result.

Charlie Kaufman is a confused L.A. screenwriter overwhelmed by feelings of inadequacy, sexual frustration, self-loathing, and by the screenwriting ambitions of his freeloading twin brother Donald. While struggling to adapt "The Orchid Thief," by Susan Orlean, Kaufman's life spins from pathetic to bizarre. The lives of Kaufman and Orlean's book become strangely intertwined as each one's search for passion collides with the other's.

Hoping that self-employment through gig economy can solve their financial woes, a hard-up delivery driver and his wife struggling to raise a family end up trapped in the vicious circle of modern-day labour exploitation.

When reporter Jean Craddock interviews Bad Blake—an alcoholic, seen-better-days country music legend—they connect, and the hard-living crooner sees a possible saving grace in a life with Jean and her young son.

Writer Paul Benjamin is nearly hit by a bus when he leaves Auggie Wren's smoke shop. Stranger Rashid Cole saves his life, and soon middle-aged Paul tells homeless Rashid that he wouldn't mind a short-term housemate. Still grieving over his wife's murder, Paul is moved by both Rashid's quest to reconnect with his father and Auggie's discovery that a woman who might be his daughter is about to give birth.

Harold Crick is a lonely IRS agent whose mundane existence is transformed when he hears a mysterious voice narrating his life.

Vada Sultenfuss is obsessed with death. Her mother is dead, and her father runs a funeral parlor. She is also in love with her English teacher, and joins a poetry class over the summer just to impress him. Thomas J., her best friend, is "allergic to everything", and sticks with Vada despite her hangups. When Vada's father hires Shelly, and begins to fall for her, things take a turn to the worse...

On the brink of turning 30, a promising theater composer navigates love, friendship and the pressure to create something great before time runs out.

Lured by their dreams of fame and fortune, three ambitious young women enter the world of show business and discover how easy it is to sink into a celebrity nightmare of ego, alcohol and pills — the beloved "dolls."

A struggling young writer finds his life and work dominated by his unfaithful wife and his radical feminist mother, whose best-selling manifesto turns her into a cultural icon.

Stevie, fresh from prison in Scotland, finds a job on a London construction site. Working conditions are poor and most of the men are working under aliases, due to immigration status and to not conflict with unemployment. Some help Stevie secure housing, squatting in a council estate. Then Stevie meets Susan, from Ireland, an aspiring singer.