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Blank-faced bug killer Bill Lee and his dead-eyed wife, Joan, like to get high on Bill's pest poisons while lounging with Beat poet pals. After meeting the devilish Dr. Benway, Bill gets a drug made from a centipede. Upon indulging, he accidentally kills Joan, takes orders from his typewriter-turned-cockroach, ends up in a constantly mutating Mediterranean city and learns that his hip friends have published his work -- which he doesn't remember writing.

Hoping that self-employment through gig economy can solve their financial woes, a hard-up delivery driver and his wife struggling to raise a family end up trapped in the vicious circle of modern-day labour exploitation.

Charlie Kaufman is a confused L.A. screenwriter overwhelmed by feelings of inadequacy, sexual frustration, self-loathing, and by the screenwriting ambitions of his freeloading twin brother Donald. While struggling to adapt "The Orchid Thief," by Susan Orlean, Kaufman's life spins from pathetic to bizarre. The lives of Kaufman and Orlean's book become strangely intertwined as each one's search for passion collides with the other's.

Writer Harry Block draws inspiration from people he knows, and from events that happened to him, sometimes causing these people to become alienated from him as a result.

Writer Paul Benjamin is nearly hit by a bus when he leaves Auggie Wren's smoke shop. Stranger Rashid Cole saves his life, and soon middle-aged Paul tells homeless Rashid that he wouldn't mind a short-term housemate. Still grieving over his wife's murder, Paul is moved by both Rashid's quest to reconnect with his father and Auggie's discovery that a woman who might be his daughter is about to give birth.

When reporter Jean Craddock interviews Bad Blake—an alcoholic, seen-better-days country music legend—they connect, and the hard-living crooner sees a possible saving grace in a life with Jean and her young son.

Harold Crick is a lonely IRS agent whose mundane existence is transformed when he hears a mysterious voice narrating his life.

Vada Sultenfuss is obsessed with death. Her mother is dead, and her father runs a funeral parlor. She is also in love with her English teacher, and joins a poetry class over the summer just to impress him. Thomas J., her best friend, is "allergic to everything", and sticks with Vada despite her hangups. When Vada's father hires Shelly, and begins to fall for her, things take a turn to the worse...

On the brink of turning 30, a promising theater composer navigates love, friendship and the pressure to create something great before time runs out.

A struggling young writer finds his life and work dominated by his unfaithful wife and his radical feminist mother, whose best-selling manifesto turns her into a cultural icon.

Thane Furrows, an extremely cynical but unintentionally hilarious children's book writer, wakes up one morning, and, since pretty much everyone and everything annoys him, begins another day of complaining to himself. However, the day proves to be much different than normal when Thane begins to recieve strange phone calls, letters, and voices in his head, all indicating that something will happen at 8 o'clock. As the day goes on, Thane rants and raves about the things that annoy him, as the clock slowly ticks closer and closer to his destiny.

A writer for a greeting card company learns the true meaning of loneliness when he comes home to find his girlfriend in bed with another man.