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Clinging to a smooth, curved surface high above a sentient abyss, a woman tries to cover the few feet back to safety without losing purchase and falling to her death.

While attending a retrospect of his work, a filmmaker recalls his life and his loves: the inspirations for his films.

In a suburban landscape, the lives of several families interlace with loss, despair and personal crisis. Esther Gold has lost focus on all but caring for her comatose son, Paul, and neglects her daughter and husband. Lawyer Jim Train is devoted to his career, not his family. Helen Christianson wants to find a new spark in life, while Annette Jennings tries to rebuild hers.

Zoë is a single mother who lives with her four children in Dartford. She is poor and can't afford to buy food. One day her old flame drives by and asks her to go on a date with him. Scared that he doesn't want to go out with her, she lies and tells him that she is just babysitting the kids. This will be her first date in years.

Lee is an aunt whose life mission is to protect her orphaned nieces, Imogen and Maeve, from a self-destructing world, raising them in isolation until an outsider threatens their peaceful existence.

A dangerously disturbed Vietnam veteran struggles with life 15 years after his return home, and slowly falls into insanity from his gritty urban lifestyle.

A poor, struggling South Carolinian mother and daughter face painful choices with their resolve and pride. Bone, the eldest daughter, and Anney her tired mother, grow both closer and farther apart: Anney sees Glen as her last chance.

A psychotherapist helps a law student cope with schizophrenia in one of five interconnected tales dealing with mental illness.

Milton, a college dropout, was only supposed to cook meth for one day. Broken out of rehab by a brash young woman and her trigger-happy ("ex") boyfriend and driven to a remote cabin the woods, Milton finds himself drawn into a dangerous love triangle gone haywire. The couple's deadpan half-truths spin around Milton like a song on repeat. They seem to read him like an open book, until a mysterious message opens his eyes to his cursed existence. With unlimited ammunition, any hunting tool they could desire, and an ever-growing body count, for what did Milton really sign up?

A man on the verge of a promotion takes a mysterious hallucinogenic drug that begins to tear down his reality and expose his life for what it really is.

Grindhouse combines Robert Rodriguez's Planet Terror, a horror comedy about a group of survivors who battle zombie-like creatures, and Quentin Tarantino's Death Proof, an action thriller about a murderous stuntman who kills young women with modified vehicles. It is presented as a double feature with fictitious exploitation trailers preceding each segment.

Jon Lansdale is a comic book artist who loses his right hand in a car accident. The hand was not found at the scene of the accident, but it soon returns by itself to follow Jon around, and murder those who anger him.