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Cocky researcher Sebastian Caine is working on a project to make living creatures invisible. Determined to achieve the ultimate breakthrough, Caine pushes his team to move to the next phase — using himself as the subject. The test is a success, but when the process can't be reversed and Caine seems doomed to future without flesh, he starts to turn increasingly dangerous.

As the president of a trashy TV channel, Max Renn is desperate for new programming to attract viewers. When he happens upon "Videodrome," a TV show dedicated to gratuitous torture and punishment, Max sees a potential hit and broadcasts the show on his channel. However, after his girlfriend auditions for the show and never returns, Max investigates the truth behind Videodrome and discovers that the graphic violence may not be as fake as he thought.

When researchers rescue a fellow scientist who survived a meteorite strike in the Arctic, they discover she may not be who they think she is. Is she some-how changed?

A journey into uncharted and forbidden territory through three tales tangled in space and time.

A psychotherapist journeys inside the mind of a comatose serial killer in the hopes of saving his latest victim.

The film contains five stories set on desolate stretches of a desert highway. Two men on the run from their past, a band on its way to a gig, a man struggling to get home, a brother in search of his long-lost sister and a family on vacation are forced to confront their worst fears and darkest secrets in these interwoven tales.

Survivors of a nuclear attack are grouped together for days in the basement of their apartment building, where fear and dwindling supplies wear away at their dynamic.

When a group of misfits is hired by an unknown third party to burglarize a desolate house and acquire one rare VHS tape, they discover more found footage than they had bargained for.

Charles Dexter Ward, a wealthy scientist, uses an ancient diary and human remains to begin a terrifying and bloody pursuit for immortality.

A young woman studying the habits of webcam chat users from the apparent safety of her apartment witnesses a brutal murder online and is quickly immersed in a nightmare in which she and her loved ones are targeted for the same grisly fate as the first victim.

Grindhouse combines Robert Rodriguez's Planet Terror, a horror comedy about a group of survivors who battle zombie-like creatures, and Quentin Tarantino's Death Proof, an action thriller about a murderous stuntman who kills young women with modified vehicles. It is presented as a double feature with fictitious exploitation trailers preceding each segment.

After becoming orphaned, a lonely girl moves in with her grandparents and tries to befriend a sick, bed-ridden boy next door, despite his mother’s strong objections. Her persistence leads to a friendship, but during secret visits, she uncovers dark secrets in the boy's home.