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Zach Riley is a psychiatrist, who leaves a job at a prestigious university, to take up a job at the privately run mental institution, Millwood. What he doesn't reveal at the time of his appointment is that this was the very place where his novelist father, T.L. Pierson, spent many years of his life.

While holidaying in Ireland, a pregnant children's author finds her mental state becoming increasingly unstable, resulting in paranoia, hallucinations, and visions of a doppelgänger.

Diagnosed with a mental illness halfway through his senior year of high school, a witty, introspective teen struggles to keep it a secret while falling in love with a brilliant classmate who inspires him to open his heart and not be defined by his condition.

Virginia Cunningham is confused upon finding herself in a mental hospital, with no memory of her arrival at the institution. Tormented by delusions and unable to even recognize her husband, Robert, she is treated by Dr. Mark Kik, who is determined to get to the root of her mental illness. As her treatment progresses, flashbacks depict events in Virginia's life that may have contributed to her instability.

Filmmaker Jonathan Caouette's documentary on growing up with his schizophrenic mother -- a mixture of snapshots, Super-8, answering machine messages, video diaries, early short films, and more -- culled from 19 years of his life.

Matthew, a young schizophrenic, finds himself out on the street when a slumlord tears down his apartment building. Soon, he finds himself in even more dire straits, when he is threatened by Little Leroy, a thug who is one of the tough denizens of the Fort Washington Shelter for Men. He reaches out to Jerry, a streetwise combat veteran, who takes Matthew under his wing as a son. The relationship between these two men grows as they attempt to conquer the numbing isolation of homelessness.

When Jane is rejected by life, she spirals into a chaotic, schizophrenic world where love and normality collide with humorous consequences.

When a young girl’s sketchbook falls into a strange pond, her drawings come to life—chaotic, real, and on the loose. As the town descends into chaos, her family must reunite and stop the monsters they never meant to unleash.

A clairvoyant therapist confronts her own personal demons while trying to save a young girl who believes a malevolent entity is feeding on her.

Teenager David Clemens develops a hysterical fear that he will die if he comes into physical contact with another person. Perturbed, David's overbearing mother places him in a home for mentally disturbed young people, but David remains withdrawn from the other patients and his psychiatrist. Over time, however, David grows interested in 15-year-old Lisa, who suffers from multiple personalities – one who can only speak in rhyme, and the other, a mute.

In the year 2035, convict James Cole reluctantly volunteers to be sent back in time to discover the origin of a deadly virus that wiped out nearly all of the earth's population and forced the survivors into underground communities. But when Cole is mistakenly sent to 1990 instead of 1996, he's arrested and locked up in a mental hospital. There he meets psychiatrist Dr. Kathryn Railly and the son of a famous virus expert who may hold the key to the Army of the 12 Monkeys; thought to be responsible for unleashing the killer disease.

A psychotherapist helps a law student cope with schizophrenia in one of five interconnected tales dealing with mental illness.